Compared with the hyperuricemia group, UWP, UWE, UWB, and UWA groups downregulated the mRNA levels of URAT1 at low and high doses, respectively (Figure 6(b)), and the groups of UWP-L, UWP-H, UWE-L, and UWA-H had significantly increased OAT1 mRNA levels (Figure 6(b)). The gene discussed is SLC22A6; the disease is hyperuricemia.