Previous studies have reported the role of various factors in cardiac injury during sepsis, and the protein heme oxygenase-1 (HO-1), a rate-limiting microsomal enzyme in the catabolism of heme into carbon monoxide, free iron, and biliverdin, limited septic injury by suppressing interleukin-1β and nuclear factor-κB expression during the initial development of sepsis [6]. Here, HMOX1 is linked to Sepsis.