As for transcriptional regulation of PGC-1α through histone (de)acetylation, we have previously reported that in the TAC mouse model of heart failure, the reduced mRNA level of PGC-1α was associated with a significant decrease in H3 lysine 9 acetylation (H3K9Ac) (Figure 1A) (28). The gene discussed is PPARGC1A; the disease is heart failure.