A notable exception is Foxy-5, a peptide mimetic of WNT5A that was designed with the goal of blocking breast cancer metastasis by reconstituting a – presumably non-CTNNB1 driven –WNT5A signaling response in cancers that had lost WNT5A expression (Säfholm et al., 2008). The gene discussed is CTNNB1; the disease is breast cancer.