Given the presumed importance of WNT/CTNNB1 signaling in breast cancer stem cell maintenance (Lamb et al., 2013; Jang et al., 2015; Hou et al., 2018), it is somewhat counterintuitive that the non-canonical co-receptor ROR1 is emerging as a potential key mediator of chemoresistance in breast cancer stem cells (Zhang et al., 2019). This evidence concerns the gene ROR1 and breast cancer.