ZEB1 and Familial prostate cancer: For example, Han et al. found that HGF treatment-induced epithelial-mesenchymal transition (EMT) -like changes and increased the invasive potential of PC-3 cells in human prostate cancer through ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) and zinc finger E-box binding homeobox 1 (Zeb-1) signaling pathways (Han et al., 2016).