Cross-entity comparisons identified only a few shared homologous VH CDR3, thus revealing that the majority of stereotyped BcR IGs are “CLL-biased.” The few BcR IG sequence matches concerned sequences from autoreactive B cell clones, as well as sequences from diverse B cell lymphoproliferative disorders directly or indirectly linked to infections by certain pathogens (e.g., the hepatitis C virus in the case of CLL stereotyped subset #13) (91). Here, BCR is linked to B-cell chronic lymphocytic leukemia.