In detail, whereas TP53 aberrations were associated with inferior outcome in both M-CLL and U-CLL, trisomy 12 and/or stereotyped subset #2 membership constituted adverse prognosticators for the former whereas SF3B1 mutations and del(11q) had the most significant negative impact amongst the latter (132) (Figure 2). The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.