In detail, whereas TP53 aberrations were associated with inferior outcome in both M-CLL and U-CLL, trisomy 12 and/or stereotyped subset #2 membership constituted adverse prognosticators for the former whereas SF3B1 mutations and del(11q) had the most significant negative impact amongst the latter (132) (Figure 2). This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.