CD8A and neoplasm: The inflamed tumor profile is characterized by the infiltration of immune effector cells [e.g., CD8+ T cells and type 1 T helper (TH1) cells] and proinflammatory cytokines [e.g., interleukin (IL)-12, IL-1β, and type I and type II interferons (IFNs)] in the tumor parenchyma (5, 6).