As the TRAIL-R family is localized at 8p21.3, a locus that is prone to deletion in OSCC (2), our findings of a worse prognosis when HNSCC tumors have a lower TRAIL-R2 copy number using the TCGA cohort confirms the importance of TRAIL-R2 in tumor abrogation. Here, TNFRSF10B is linked to head and neck squamous cell carcinoma.