Assessment of PVT1 transcript levels by quantitative RT-PCR in LOVO and RKO colon cancer cell lines with acquired resistance to cisplatin, or HCT8 and HCT116 with secondary resistance to 5-FU also evidenced the transcriptional upregulation of PVT1 lncRNA (70, 157). The gene discussed is PVT1; the disease is malignant colon neoplasm.