This miRNA is frequently downregulated in colorectal tumors and acts predominantly as a tumor suppressor element by targeting phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and Runt-related transcription factor 2 (RUNX2), both crucial for the development of tumors (72, 130, 131) (Figure 5). This evidence concerns the gene RUNX2 and colorectal neoplasm.