PVT1 Sv-203 when amplified with qPCR primers that could co-amplify Sv-202 and Sv-211 (66) (two isoforms that according to genome-wide RNAseq profiling have no detectable expression in colorectal malignancies) correlates with advanced stage (III-IV), lymph node metastasis, venous invasion, and decreased overall survival (66, 70). Here, PVT1 is linked to metastatic malignant neoplasm in the lymph nodes.