At the same time, in DEPs detected by iTRAQ technology, we found that cell cycle and apoptosis regulatory protein 2 (CCAR2) decreased after BAG2 knockdown, suggesting that CCAR2 may act as a downstream factor of BAG2 to form miR186-BAG2-CCAR2 axis to regulate gastric cancer cell cycle and apoptosis. The gene discussed is CCAR2; the disease is gastric cancer.