It is clear that several studies attest to the fact that C. afer acts as an antidiabetic agent via biochemical mechanisms including restitution of pancreatic β-cell function, amelioration of insulin resistance by sensitizing receptors, inhibition of liver gluconeogenesis, enhanced glucose absorption, and inhibition of G-6-Pase, α-amylase, and α-glucosidase activities. This evidence concerns the gene G6PC1 and Insulin resistance.