The inclusion criteria of the SCARLET study were based on a post hoc analysis of a randomized placebo-controlled phase 2b study, in which recombinant human soluble thrombomodulin (rhsTM) had a non-significant effect on the 28-day mortality rate in patients with sepsis and suspected DIC (17.8% vs 21.6% in the placebo group) [8]. Here, THBD is linked to Sepsis.