To investigate the association between such immunosuppression and clinical outcome, as well as to find any immune biomarker for the prediction of clinical outcome, based on the clinical data, we also compared the different distributions of PD-1 + Tim-3+ T cells in the BM and PB from AML patients with CR and NCR after the first cycle of chemotherapy who we could follow up for clinical outcome. The gene discussed is HAVCR2; the disease is acute myeloid leukemia.