The results indicated that the significantly increased PD-1 + Tim-3 + CD3+ T cells in the BM and PD-1 + Tim-3 + CD4+ T cells in PB was related to NCR, which was in agreement with the finding that PD-1 and Tim-3 co-expression increases during AML progression in an advanced AML mouse model [24]. Here, CD4 is linked to acute myeloid leukemia.