We demonstrate for the first time that the combination of M‐CSF, TGF‐β and VEGF, all present in the BC primary tumor microenvironment, converts monocytes into suppressive CD163highCD86lowIL‐10high MΦ, whereas GM‐CSF and IFN‐γ, master M1‐MΦ inducers, were not detected in SNDils. The gene discussed is CSF2; the disease is breast cancer.