We previously performed genome-wide DNA methylation and expression profiling of patient-matched normal, dysplasia, and carcinoma in situ (CIS) or OSCC samples obtained from the oral cavity (GEO Accession # GSE46802), with the sphingomyelin phosphodiesterase 3 (SMPD3) gene promoter identified as a site of frequent hypermethylation and silencing in dysplasia and CIS/OSCC samples as compared with normal controls [5]. Here, SMPD3 is linked to in situ carcinoma.