SMPD3 and neoplasm: In agreement with our previous observations, we found a significant increase in the average β-value (Student’s t-test with Welch’s correction, t (91.64) = 17.94, p < 0.0001; Figure 2A) and concomitant decrease in the average expression of SMPD3 (Student’s t-test, t (278) = 3.922, p = 0.0001; Figure 2B) in tumor samples as compared with normal samples.