NFKB1 and obesity due to melanocortin 4 receptor deficiency: Obesity-induced oxidative stress causes dysregulated expression of inflammation-related adipokines in the adipose tissue [29], which is promoted by the inflammatory signal transcription factor NF-κB that plays a key role in oxidative stress-induced dysregulation of adipokine expression and is recognized as a major mediator of oxidative stress-induced signal transduction in adipose cells [37, 38].