The clinical and demographic characteristics of the studied patients were as follows: 39.6 ± 11.5 years old; 51.2% male; duration of diabetes 22.37 ± 3.47 years; BMI 24.33 ± 3.47 kg/m [2]; HbA1C 8.42 ± 1.48%; and insulin dose of 0.71 ± 0.22 UI/kg/day. This evidence concerns the gene INS and diabetes mellitus.