Conerning TSLP, a recent research suggested a role of TSLP in directly promoting T helper 2(Th2) cell effector function and support the notion of TSLP as a key driver of Th2 inflammation [29], while the crucial effects of Th2 lineage in the pathogenesis of allergy have been always highlighted with the associations identified in or near key Th2 pathways genes. The gene discussed is TSLP; the disease is Allergy.