Two stop-gain SNVs were identified from the p53 genes MSH2 (Chr2: 47705428; rs63751155) and TP53 (Chr17: 7579315; COSM326717; COSM3388232; COSM326718; COSM3388233; COSM326716) in initial tumours; both variants were predicted to be pathogenic by FATHMM-MKL (). The gene discussed is MSH2; the disease is neoplasm.