Recurrent IDHWT tumours had SNVs in genes in the RTK/Ras/PI(3)K (43%; 3/7), WNT signalling (57%; 4/7), and p53 pathways (29%) in the genes BRCA1 (14%; 1/7) and BRCA2 (14%; 1/7) and GNAS (14%; 1/7). This evidence concerns the gene GNAS and neoplasm.