This process can be subverted by inhibiting antigen presentation machinery directly on tumor epithelial cells [59], deactivating immune antigen-presenting cells (such as dendritic cells), intercepting cytotoxic CD8+ T-cells and natural killer cells, avoiding autophagy from macrophages, activating CAF-based desmoplasia, and other mechanisms [60]. The gene discussed is CD8A; the disease is neoplasm.