Although no specific clinical treatment is required for Rotor syndrome, the absence or dysfunction of the OATP1B1 and OATP1B3 hepatic proteins may have serious consequences for the hepatic uptake and clearance of numerous commonly used drugs, including anticancer drugs and some angiotensin-converting enzyme inhibitors (Kalliokoski and Niemi, 2009; Niemi et al., 2011; Shitara, 2011). Here, SLCO1B3 is linked to Rotor syndrome.