To better understand the role of peripheral Mo/MΦ in preservation of excitatory synapses within AD-relevant cortical and hippocampal regions, we analyzed both pre- and postsynaptic density in substructures of ENT and HIPPO following weekly s.c. injections of GA immunization or monthly i.v. injections of CD115+ MoBM into the peripheral blood (schematic of in vivo experiment in Figure 5C). This evidence concerns the gene CSF1R and Alzheimer disease.