Two xenograft models of leiomyosarcoma in mice (via LMS04 and LMS05 tumor cell transplant) have also been treated with a humanized anti-CD47 monoclonal antibody, which increases the levels of macrophage-mediated phagocytosis of leiomyosarcoma tumor cells and inhibits the growth of primary tumors and the formation of lung metastases after primary tumor graft resection (30). This evidence concerns the gene CD47 and leiomyosarcoma.