CD47 blockade can promote the adaptive immune response, e.g., when treatment with an anti-CD47 antibody induced antigen-specific CD8+ T-cell proliferation and macrophage phagocytosis but reduced regulatory T-cell number in a colon cancer model, suggesting that anti-CD47 treatments can facilitate adaptive T-cell immune response (71). The gene discussed is CD47; the disease is malignant colon neoplasm.