For example, studies by Russ et al. demonstrated that CD47 is overexpressed in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) cells when compared with normal myeloid cells from healthy mice or humans; these authors also showed that higher CD47 expression levels were associated with worsened therapeutic response and prognosis (35). Here, CD47 is linked to acute myeloid leukemia.