CD47 and acute myeloid leukemia: Pietsch et al. (88) assessed the anti-leukemia activity of several anti-CD47 antibodies in mice and cynomolgus monkeys; after transplantation of HL60, MV4-11, and Kasumi-3 AML cells, animals were treated with the Fc region of various anti-CD47 monoclonal antibodies (including C47B157, C47B161, C47B222, and B6H12.2) that led to reductions in the levels of peripheral AML cells.