In addition to directly inducing cell death via blockade of CD47-SIRPα signaling, this study showed that CC2C6 synergizes with low-dose chemotherapeutic agents that induce classical apoptosis, resulting in an effective combination of treatments without the need for high-dose chemotherapy, which is often associated with long-term side-effects in pediatric ALL patients (91). This evidence concerns the gene CD47 and acute lymphoblastic leukemia.