Feliz-Mosquea et al. (81) performed a quantitative high-throughput screening of anti-cancer drugs and administered an anti-CD47 antibody to a mouse 4T1 breast cancer model and concluded that blocking CD47: (i) enhances anthracycline-mediated tumor cytotoxicity; (ii) enhances macrophage-mediated cytotoxicity of breast cancer cells; and (iii) prevents anthracycline-mediated cardiomyocyte and tissue toxicity. Here, CD47 is linked to cancer.