Compared to both normal peripheral blood and germinal center B cells, CD47 is more highly expressed on a large subset of primary patient samples from multiple B cell non-Hodgkin lymphoma (NHL) subtypes, including diffuse large B cell lymphoma (DLBCL), B cell chronic lymphocytic leukemia (B-CLL), mantle cell lymphoma (MCL), follicular lymphoma (FL), marginal zone lymphoma (MZL), and pre-B acute lymphoblastic leukemia (pre-B ALL), while high expression of CD47 is predictive of poor prognosis in NHL patients (42). Here, CD47 is linked to diffuse large B-cell lymphoma.