CD47 and acute lymphoblastic leukemia: Interestingly, treatment of human or murine acute lymphoblastic leukemia (ALL) T-cells with a soluble CD47 agonist peptide induces changes in reactive oxygen species (ROS) production (89) and caspase-independent and calcium-dependent leukemia cell death; this study also showed that PKHB1-treated cells could be used as a prophylactic to prevent tumorigenesis (90).