A recent study from Le Coz et al. highlighted that part of the naïve CD4 T cells from CVID patients with autoimmune cytopenias (AIC) are skewed toward a follicular commitment based on their expression of specific markers (CXCR5, PD-1, CCR7, CD38, ICOS, T-cell factor 1). The gene discussed is CD4; the disease is common variable immunodeficiency.