Additional strategies have been implemented to prevent infection (Demberg and Robert-Guroff, 2012), such as: (i) syringe and needle exchange programs among intravenous drug users (IDU), (ii) oral/systematic pre-exposure prophylaxis (PrEP), (iii) post-exposure prophylaxis (PEP), (iv) gel base microbicides, (v) male circumcision, (vi) CCR5 co-receptor blocking molecules or permanently knocking out expression of CCR5, and (vii) “shock-and-kill” therapy using latency-reversing drugs such as HDAC inhibitors, to reduce the latent reservoirs in patients. This evidence concerns the gene CCR5 and infection.