In support to the aforementioned evidences, obese women usually suffer from hyperleptinemia, hyperandrogenemia, amplified the aromatization of androgens to estrogens in peripheral tissues, changed secretion of gonadotrophin, declined sex hormone binding globulin, and changed neuroregulation of the hypothalamic-pituitary-gonadal axis. The gene discussed is SHBG; the disease is polycystic ovary syndrome.