HMOX1 and obesity due to melanocortin 4 receptor deficiency: Notably, UCB derived from HMOX1 in endothelial cells has been shown to be able to scavenge NADPH oxidase derived ROS, impairing leukocyte transmigration and inflammatory responses (Vogel and Zucker, 2016), as discussed in Section “Effects on Adhesion Molecule Expression: Implications for Obesity, Atherosclerosis and Chronic Inflammatory Diseases.”