Intriguingly, CAV1 is overexpressed in various liver disease and HCC (but not in non-alcoholic fatty liver disease, own observations), suggesting that its expression may enable diseased hepatocytes to escape from detrimental TGF-β-induced responses (Nwosu et al., 2016; Moreno-Caceres et al., 2017). Here, TGFB1 is linked to liver disorder.