Besides providing a new point of view for a deeper understanding on the entanglement from whole gene signatures in healthy hepatocytes, it will also be of relevance to investigate CAV1 and TGF-β correlation in disease settings, such as non-alcoholic steatohepatitis, cirrhosis, or HCC where CAV1 is often found to play a role. The gene discussed is CAV1; the disease is metabolic dysfunction-associated steatohepatitis.