Angiogenic and antiangiogenic factors such as VEGF (Behl and Kotwani, 2015), pigment epithelium derived factor (PEDF) (Ibrahim et al., 2015), and angiopoietin (Bento et al., 2010) released by the retina under hyperglycemia act on NV. The gene discussed is SERPINF1; the disease is Hyperglycemia.