For example, recombinant human soluble thrombomodulin (rTM) suppressed the expression of serum HMGB1 in monocrotaline-induced sinusoidal obstruction syndrome; thus, these results indicated that rTM decreased circulatory HMGB1 and inhibited active neutrophil accumulation, with significantly reduced serum ALT levels and an improved patient outcome (Nakamura et al., 2014). This evidence concerns the gene HMGB1 and hepatic veno-occlusive disease.