Our results showed that IL-6, IL-1β, and TNF-α were dramatically increased in the serum of asthma rats as well as augmented spliced XBP-1 (XBP-1s) both in cultured fetal rat hippocampal neurons and lung tissues of asthma rats, while significantly decreased was then detected with treatment of icariin, which further indicating the suppressive effect of icariin on ER stress in asthma rat models. Here, XBP1 is linked to asthma.