Comparing to those derived from healthy individuals, urinary exosomes derived from autosomal dominant PKD (ADPKD) patients with PKD1 gene mutation had decreased levels of polycystin-1 and polycystin-2, but increase of transmembrane protein 2 (Hogan et al., 2015). This evidence concerns the gene CEMIP2 and autosomal dominant polycystic kidney disease.