Additional pro-arrhythmic mechanisms such as increased dispersion of repolarization can also provide the substrate for the development of reentrant arrhythmia, and drugs with hERG blockage effects can amplify the intrinsic spatial dispersion of repolarization (Antzelevitch, 2005; Dutta et al., 2016). The gene discussed is KCNH2; the disease is cardiac arrhythmia.