Potential key targets NRLP3/ASC/CASP1/IL1B that associated with the negative regulation of in NOD-like receptor signaling pathway were further verified in monosodium urate-induced THP-1 cells, and a plausible mechanism for the multitarget effects of JSCBR on gouty arthritis was consequently proposed (Figure 8). The gene discussed is CASP1; the disease is gout.