NLRP3 and gout: Among the 51 putative targets and 11 related pathways of JSCBR associate with gouty arthritis, it was discovered that IL-6, IL-1β, CASP1, and NLRP3 were relatively important targets evaluated by topological parameters, which are involved in NOD-like receptor, Toll-like receptor, cytokine-cytokine receptor interaction, and cytosolic DNA-sensing signaling pathways.