An increasing body of evidence indicates that activation of PI3K/Akt and inhibition of GSK3β play a neuroprotective role in many brain injury models, including experimental ischemic stroke (Valerio et al., 2011), subarachnoid hemorrhage-induced early brain injury (Ma et al., 2016), traumatic brain injury (Zhang et al., 2018), and intracerebral hemorrhage (Chen et al., 2019b). This evidence concerns the gene AKT1 and intracerebral hemorrhage.