SLC12A2 and asthma: One explanation for these results is that significant relief of asthma by loop diuretics might need the action of these drugs at more sites that are related to pulmonary function, since the expression and asthmatic upregulation of NKCC1 have also been found in alveolar epithelial cells, alveolar type II cells, T lymphocytes in the lungs (Wang et al., 2011) and airway sensory neurons in the nodose ganglion (Mazzone and McGovern, 2008).