Meanwhile, in other study, Igci et al. probed autophagy-related genetic profile of MS individuals and observed that many autophagy-related genes significantly over expressed in MS patients compared to healthy controls, including ULK1, ULK2, FOXO1, Bcl-2, Htt, UVRAG, Atg2B, Atg4C, Atg5, TMEM74, DAPK1, EIF2AK3, Atg11, p62, PIK3R1. This evidence concerns the gene PIK3R1 and myeloid sarcoma.