SIAH1 and colorectal carcinoma: To evaluate whether Siah1 plays a role in the proliferation of human CRC cells, medium expression cell lines HCT116/SW480 were selected to follow up subsequent functional study (Additional file 4: Figure S2C), stable Siah1 expressing CRC cell lines SW480/Siah1 and HCT116/Siah1 were established (Fig. 2a).