SIAH1 and colorectal carcinoma: The results of wound-healing assays and transwell chamber invasion assays showed that overexpression of Siah1 in SW480 and HCT116 inhibited the migratory speed and number of CRC cells (Fig. 3a, b; transwell: SW480/Siah1: P < 0.0001; HCT116/Siah1: P < 0.05), compared with control cells.