They also had lower levels of Foxp3 expression in CD4(+)Foxp3(+) cells, as well as decreased CD4(+)IL-17(+) cells, and a lower ratio of IL-17/IFN-γ CD4+ T-cells, indicating that a change in liquid acidity dramatically alters the intestinal microbiome, the presence of protective Th17 and Treg cells, and the incidence of diabetes [54]. Here, CD4 is linked to diabetes mellitus.