Organophosphates (OPs) are chemical substances used in insecticides, herbicides, etc., which inhibit acetylcholine esterase; animal studies have shown that prolonged intake of the OP insecticide monocrotophos induces hyperglycemia, dyslipidemia, cardiac oxidative stress, and myocardial infarction in rats [31] An altered hepatic gluconeogenesis mediated by OP-degrading gut microbiota has been demonstrated to be the key mechanism underlying OP-induced hyperglycemia. This evidence concerns the gene ACHE and Hyperglycemia.