TP53 and discoid lupus erythematosus: In this context, cell cycle regulation, p53 signaling, TGF-β signaling, thyroid hormone signaling, and cancer pathways were shared between miR-21, miR-31, and miR-23b (expressed in SCLE) and miR-146a, miR-1246, and miR-150 expressed in DLE patients (Figure 4).