CAPS is a spectrum of diseases caused by mutations in the NLRP3 gene and including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and chronic infantile neurological cutaneous and articular syndrome (CINCA), the latter also known as “neonatal onset multisystem inflammatory disease” or NOMID. This evidence concerns the gene NLRP3 and cryopyrin-associated periodic syndrome.