Therefore, clinical clues have been proposed to identify among patients with idiopathic recurrent acute pericarditis those who potentially might carry TNFRSF1A gene mutations: a positive family history for either pericarditis or recurrent fevers, a high rate of recurrences beyond the first year of disease, colchicine resistance, and the need for immunosuppressants to achieve control of the disease should induce a clinical suspicion of TRAPS [64, 67]. Here, TNFRSF1A is linked to pericarditis.