NLRP3 and familial cold autoinflammatory syndrome: CAPS is a spectrum of diseases caused by mutations in the NLRP3 gene and including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and chronic infantile neurological cutaneous and articular syndrome (CINCA), the latter also known as “neonatal onset multisystem inflammatory disease” or NOMID.