Interestingly, functional oligomeric NLRP3-inflammasome particles able to amplify extracellular and intracellular caspase-1 proinflammatory activities were detected in the serum of patients with MWS and severe CINCA phenotypes (carrying the p.R260W, p.T348M, p.A439T, and p.D303N mutations) and in CAPS patients with low-grade somatic NLRP3 mosaicism [113]. Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.