CAPS is a spectrum of diseases caused by mutations in the NLRP3 gene and including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and chronic infantile neurological cutaneous and articular syndrome (CINCA), the latter also known as “neonatal onset multisystem inflammatory disease” or NOMID. Here, NLRP3 is linked to CINCA syndrome.