Similarly, according to our results, the relative protein expression of IL-6, JAK2, p-JAK-2, STAT3 and p-STAT-3 in intestinal tissues of mice in the colitis model group were significantly lower than those in the Control and Control’ group, and the phosphorylation levels of JAK2 and STAT3 were also significantly decreased. This evidence concerns the gene STAT3 and colitis.