Therefore, this experiment detected the expression of ST2 on the macrophages in MLN (mesenteric lymph node) and IL-33 in colon tissue to verify whether IL-33 and its receptor ST2 play a role in the process of recombinant protein promoting tissue repair of TNBS (2,4,6-Trinitrobenzenesulfonic acid solution)-induced colitis. The gene discussed is IL33; the disease is colitis.