The CMG helicase is not a self-contained enzyme working in isolation, but rather is part of a large complex machine called a replisome, which incorporates proteins such as DNA polymerases, topoisomerases, cofactors, and other subunits.[56] Perhaps as a result of Myc-driven genomic instability/changes and selection pressure, some of these associated proteins will be found in future experiments to be deregulated in tumor cells, compensating for deficiencies in CMG function and further creating tumor heterogeneity in the surviving cells. The gene discussed is CASK; the disease is neoplasm.