In fact, it may be that one reason many chemotherapy drugs, including alkylating, crosslinking, and intercalating agents, and drugs that block nucleotide synthesis or topoisomerases, are effective in cancer management is due to tumor-specific conditions (e.g., Myc deregulation) in which recovery from fork-stalling drugs is impaired as a result of lowered reserve MCM/CMG capacity. The gene discussed is MYC; the disease is neoplasm.