BRAF and colorectal carcinoma: Recently, our group identified fascin1 as overexpressed in serrated adenocarcinoma (SAC), a WHO-recognized histological subtype of colorectal carcinoma (CRC), which is characterized by worse prognosis6 and a more active invasive front as evidenced by a higher occurrence of tumor budding7, E-cadherin loss, and more frequent KRAS or BRAF mutations compared with conventional CRC8–10.