FMO5 and central nervous system cancer: As Kraft et al. pointed out, although the design of the study by Munson et al. was based on the inhibition of NADPH oxidase by imipramine blue, glioma cells treated in vitro showed a dramatic reorganization of their actin cytoskeleton, with marked loss of actin bundle-based protrusions and extensions28,29, which is consistent with our findings of a direct effect of imipramine causing loss of fascin1 function28.