We found that EMT-related genes such as Ctgf55 and Sparc56,57 were first activated in basal tumor cells, and that their expression extended and decreased within the cell population (Ctgf) itself or throughout both CSC-like subpopulations (Sparc) as tumorigenesis proceeded (Fig. 5f, Supplementary Fig. 13). The gene discussed is SPARC; the disease is neoplasm.