IDH2 and neoplasm: Magnetic resonance (MR) imaging (MRI) is an ideal solution for characterizing physiologic and molecular features of GBMs in a noninvasive manner.[13,14] MRI equipped with specialized MR spectroscopic techniques was proved to be able to detect the in vivo accumulation of d-2HG, the oncometabolite produced from IDH mutations.[15,16] Other MRI techniques, including perfusion and diffusion imaging, were also proposed to distinguish differences between WT and mutant IDH GBMs.[17] Interpretation of the IDH status from MRIs can be realized from heterogeneous patterns within the tumor area.