PIK3CA and breast carcinoma: Since a case-control dataset was not readily available to us to test associations between the GReX of genes with breast cancer risk, we construct the weighted burden test, as in FUSION [14], for the GReX of AURKA, CAPN13, PIK3CA, and SERPINB5 in the GWAS summary statistics for breast cancer risk in AA women available from BCAC using the iCOGs dataset and additional GWAS [37–39].