Since a case-control dataset was not readily available to us to test associations between the GReX of genes with breast cancer risk, we construct the weighted burden test, as in FUSION [14], for the GReX of AURKA, CAPN13, PIK3CA, and SERPINB5 in the GWAS summary statistics for breast cancer risk in AA women available from BCAC using the iCOGs dataset and additional GWAS [37–39]. The gene discussed is SERPINB5; the disease is breast cancer.