CASP3 and cancer: SR-T100, a newly patented product extracted from Solanum incanum, which contains solamargine alkaloid as the main active ingredient, is a potent inducer of apoptosis in different cancer cells that upregulates the expression of death receptor signaling cascades [42, 43]; it downregulated Bcl-XL but upregulated Bax and caused caspase-3 activation of the mitochondrial pathway [44, 45].