The present study reports the capability of ethanolic extract of C. asiatica (RECA) in inhibiting acetylcholinesterase (AChE) activity and its possible association in suppressing the elevated expression of pro-inflammatory cytokine/mediators and oxidative stress via in vitro and in vivo models of Alzheimer’s disease (AD). The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.