Although immunohistochemical analysis showed no correlation between CDKN1A, TP53 and PTEN expression in chRCC (TP53 and PTEN positivity was rare in our chRCC cohort; data not shown), the loss of function of the latter two tumor suppressors may have significant impact on CDKN1A regulation. Here, TP53 is linked to chromophobe renal cell carcinoma.