Although immunohistochemical analysis showed no correlation between CDKN1A, TP53 and PTEN expression in chRCC (TP53 and PTEN positivity was rare in our chRCC cohort; data not shown), the loss of function of the latter two tumor suppressors may have significant impact on CDKN1A regulation. The gene discussed is CDKN1A; the disease is chromophobe renal cell carcinoma.